Overview of Vinpocetine
Vinpocetine is a semisynthetic derivative of the alkaloid vincamine, which is originally obtained from the periwinkle plant Vinca minor. In different laboratory settings, researchers investigate Vinpocetine for its possible role in neuroprotection and potential cognitive-supportive properties.
Chemical Properties
| PubChem CID | 443955 |
| Molecular Formula | C22H26N2O2 |
| Synonyms | vinpocetine
42971-09-5 Cavinton Ceractin Bravinton |
| Molecular Weight | 368.3 g/mol |
| IUPAC | (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide |
Working Mechanism of Vinpocetine
Vinpocetine has been shown to support cerebral blood flow and neuronal signaling in research models. Preliminary studies have suggested that Vinpocetine may mediate this process by inhibiting phosphodiesterase type 1 (PDE1), which may increase cAMP and cGMP levels.
Researchers have also noticed that Vinpocetine may block voltage-dependent sodium channels and modulate calcium entry. Both mechanisms may help reduce neuronal excitotoxicity. Additionally, research suggests it may improve cerebral circulation and provide neuroprotective effects through antioxidant actions.
Potential Benefits of Vinpocetine
Vinpocetine is still under investigation; however, preliminary studies suggest the following potential benefits in research subjects.
- Enhances cerebral perfusion in experimental models.
- Reduces oxidative stress in neuronal research models.
- Improves cognitive metrics in experimental models.
- Inhibits NF-kB-mediated inflammatory pathways in research models.
- Promotes mitochondrial efficiency in experimental models.
Potential Side Effects of Vinpocetine
The following are a few of the side effects observed in research subjects. However, long-term research is required to understand the full safety profile of this compound.
- Induces mild gastrointestinal disturbances in experimental models.
- Alters blood pressure parameters in research models.
- Causes transient flushing in experimental models.
- Modulates cardiac rhythm in research models.
- Produces dizziness-like responses in experimental models.
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FAQs
What is the half-life of Vinpocetine?
In research subjects, the estimated half-life of Vinpocetine is about 1-2 hours, though variability is observed across experimental conditions.
What is the shelf-life of Vinpocetine?
Vinpocetine in its pure powder form is generally stable for up to 2 years when stored in a cool, dry, and light-protected environment. More validation may be required in specific research settings.
Does Vinpocetine degrade over time?
Yes, Vinpocetine can degrade when exposed to light, moisture, or elevated temperatures. Controlled storage conditions are necessary for maintaining stability in preclinical models.
Which compounds are chemically related to Vinpocetine?
Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine, originally obtained from the plant Vinca minor. It belongs to the class of indole alkaloids investigated in various research contexts.
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